专利名称：MUTEINS OF HUMAN NEUTROPHIL
GELATINASE-ASSOCIATED LIPOCALIN ANDRELATED PROTEINS
发明人：SKERRA, Arne,SCHLEHUBER, Steffen申请号：EP02772321.2申请日：20020918公开号：EP1430131A2公开日：20040623
摘要：Disclosed is a method for generating a mutein of a protein selected from thegroup consisting of human neutrophil gelatinase-associated lipocalin (hNGAL), rat alpha2- microglobulin-related protein (A2m) and mouse 24p3/uterocalin (24p3), said muteinhaving detectable affinity to a given target. The method comprises the step of subjectingthe protein to mutagenesis at one or more of the sequence positions which correspondto the sequence positions 33 to 54, 66 to 83, 94 to 106, and 123 to 136 of hNGAL,resulting in one or more mutein(s) of the protein. Also disclosed are muteins obtainableby this method.
申请人：Pieris ProteoLab AG
地址：Lise-Meitner-Strasse 30 85354 Freising DE
国籍：DE
代理机构：Viering, Jentschura & Partner
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