专利名称：INTRACELLULAR DELIVERY OF SMALL
MOLECULES PROTEINS AND NUCLEIC ACIDS
发明人：KARAS, Michael申请号：EP04717355.4申请日：20040304公开号：EP1601373A2公开日：20051207
摘要：An amino acid sequence Arg-Lys-Met-Leu-Lys-Ser-Thr-Arg-Arg-Gln-Arg-Arg(SEQ ID NO:1) functions as a protein transduction domain (PTD) and is capable of
delivering small molecules, proteins, and nucleic acids to an intracellular compartment ofa cell. An amino terminal lysine linker improves the efficiency of the PTD. A nuclearlocalization signal can be used to target the PTD to a cell's nucleus. The PTD can be usedin PTD-cargo moiety complexes that can reversibly immortalize cells and increase cellviability in culture.
申请人：Biowhittaker Technologies, Inc.
地址：8830 Biggs Ford Road Walkersville, MD 21793 US
国籍：US
代理机构：Tombling, Adrian George
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